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Included clinical studies were reviewed and categorized according to the pathology and surgical resection strategy, and experimental studies according to the animal. Suitable articles were selected based on predefined eligibility criteria following the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines. Methods: A systematic literature search of several databases (PubMed, EMBASE, Medline) was performed prior to July 2020. This article aims to provide a systematic overview for translational research by establishing the current evidence on available clinical studies and experimental models reporting on intracranial FN injury. When surgical damage occurs, commonly known reconstruction strategies are often associated with poor functional recovery. 12 Department of Biomedical Engineering, Center for Bioengineering and Regenerative Medicine, University of Basel, Basel, Switzerland.īackground and purpose: Tumorous lesions developing in the cerebellopontine angle (CPA) get into close contact with the 1st (cisternal) and 2nd (meatal) intra-arachnoidal portion of the facial nerve (FN).11 Department of Biomedicine, Brain Ischemia and Regeneration, University of Basel, Basel, Switzerland.
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10 Department of Neurosurgery, University Hospital of Basel, University of Basel, Basel, Switzerland.9 Department of Surgery, Biomaterials and Neuro Tissue Bioengineering, University of Geneva, Geneva, Switzerland.8 Department of Plastic Surgery, University Hospital Geneva, Geneva, Switzerland.7 Department of Neurosurgery, University Malaya Specialist Centre, University of Malaya, Kuala Lumpur, Malaysia.6 Department of Neurosurgery, Kantonsspital Luzern, Lucerne, Switzerland.5 Department of Neurosurgery, Kantonsspital Aarau, Aarau, Switzerland.4 Integrierte Psychiatrie Winterthur - Zürcher Unterland, Winterthur, Switzerland.3 Department of Biomedical Engineering, Biomaterials Science Center, University of Basel, Allschwil, Switzerland.2 Department of Oto-Rhino-Laryngology, Nanavati Super Speciality Hospital, Mumbai, India.1 Department of Neurosurgery, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany.